Our Mission

Alzheimer's disease is a very difficult disease to treat, and the field is crowded with companies hoping to see success with their treatments.
Pentara Corporation specializes in Alzheimer's disease clinical study design and efficacy analysis with at least 95% of Pentara's business devoted to the planning and implementation of efficacy analyses in Alzheimer's disease.
The reason for this highly specialized approach is that Pentara is a small company, and the field of Alzheimer's disease is progressing rapidly in terms of measurement of disease, population selection and efficacy analysis.
In order to be the very best at what we do, we have restricted ourselves to a field in which we can be on the cutting edge and offer our customers the reassurance that at the end of their clinical trial
-- whether it fails or succeeds --
they don't have to question whether they have measured the right outcomes and analyzed them in the best way.

We want them to be able to present results to outside audiences in a compelling way in order to move forward with confidence that decisions have been based on solid scientific evidence.

 Our Services

Pentara has two different business arrangements that suit the needs of their clients in the Alzheimer's disease field. The first is an arrangement where the primary service performed by Pentara is improving the planning of the clinical trial by optimizing the population selection, the efficacy outcome measurement and calculation, and the statistical analysis of the efficacy outcome. This arrangement is appropriate when a company has experience in Alzheimer's disease, but wants to venture into a new population, consider a new outcome, or improve the analysis methods in order to be more confident that the study design being planned is customized to the new project being considered. In most of these cases, the company is performing their own statistical analyses, programming their own tables, figures and listings, and has a staff that are either already experienced with Alzheimer's disease, or ready to become experienced as part of a long term commitment to this field. Often, these types of arrangements lead to publications or presentations of the results in order to share the insights learned with the field.

The second type of arrangement is one where the primary service performed by Pentara is the production of efficacy tables, and figures. This arrangement is more appropriate when a company is new to Alzheimer's disease and is performing a study in a population that is already well-studied with an outcome that is standard. Pentara has standard tables and figures that reflect the best approaches currently used in the Alzheimer's disease field. As the field progresses, these standard tables and figures are updated to reflect current thinking. The analyses in this case are likely to be traditional, with some updating, and Pentara would assist in writing the analyses into the protocol (along with calculation of the sample size) and the statistical analysis plan. In this case, the production of all of the tables, figures and listings can be performed by Pentara Corporation, but it is important that the efficacy analyses are performed by Pentara*. A combination of the two approaches may be desired, particularly in the case when the company is interested in optimizing the analysis or the outcomes for the specific study being planned, but when most of the aspects of the study design are standard.
*In the past, Pentara has offered the option of writing the protocol statistical section and the efficacy analysis section of the statistical analysis plan in cases when all analyses -- efficacy and non-efficacy -- are being performed by an outside group, but this has not proven to be in the best interest of our clients. In some cases, the outside companies performing the analyses have not performed them in the intended way, or have made decisions about the details of the analysis that were not consistent with the plan and the result was that the company was unsure whether the inconsistencies in the results were due to lack of a treatment effect or due to the decisions made during the analysis process.


Hendrix SB: Measuring clinical progression in MCI and pre-MCI populations: Time as the Gold Standard. Commisioned review article currently under review, Alzheimer’s Research & Therapy 2012

Hendrix SB: Requiring an amyloid-β1–42 biomarker may improve the efficiency of a study, and simulations may help in planning studies. Alzheimer’s Research & Therapy 2011, 3:X.

Shankle R, Atri A, Hendrix S: Improving measurement methodology to detect treatment effect in clinical trials [abstract]. The Journal of Nutrition, Health & Aging© Volume 15, Supplement 1, 2011, s3.

Vellas B, Aisen P, Sampaio C, Carrillo M, Scheltens P, Scherrer B, Frisoni B, Weiner M, Schneider L, Gauthier S, Gispen-Wied C, Hendrix S, Feldman H, Cedarbaum J, Petersen R, Siemers E, Andrieu S, Prvulovic D, Touchon J, Hampel H; Prevention Trials in Alzheimer’s Disease: AN EU-US task Force report. From the Toulouse Task Force 2010

Hendrix SB, Wilcock GK; What We Have Learned from the Myriad Trials. Journal of Nutrition, Health and Aging. 2009 Apr: 13(4):362-364.

Wilcock GK, Black SE, Hendrix SB, Zavitz KH, Swabb EA, Laughlin MA; Tarenflurbil Phase II Study investigators (2008) Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: a randomised phase II trial. Lancet Neurol. 2008 Jun;7(6):483-93. Epub 2008 Apr 29.

Vellas B, Andrieu S, Sampaio C, Coley N, Wilcock G; European Task Force Group (incl. Hendrix S). Endpoints for trials in Alzheimer's disease: a European task force consensus. Lancet Neurol. 2008 May;7(5):436-50.

Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo EH (2007) Safety, Tolerability, Pharmacokinetics, and Abeta Levels After Short-term Administration of R-flurbiprofen in Healthy Elderly Individuals. Alzheimer Dis Assoc Disord. 21 (4):292-299.

 Job Opportunities

Pentara is always interested in connecting with experienced SAS programmers who are interested in part time work. If you have at least 3 years of clinical trial programming experience in SAS, and you are interested in part-time programming work (remote),
please contact Suzanne Hendrix (shendrix at pentaracorp dot com).
Summer Internships
Summer internships are coordinated through Kent Hendrix.
Please send resumes to khendrix@pentaracorp dot com.
Software Architect
ASP.NET Developer
Web Designer
Software Tester

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 About Us

President and CEO
Suzanne Hendrix received her Ph.D. in Mathematics from Boston University and has spent the last 21 years as a statistician focusing on clinical trials research in many different indications. She has extensive experience designing clinical trials, writing statistical analysis plans, running analyses, writing statistical reports, interacting with the FDA and preparing manuscripts for publication. She is experienced at communicating statistical concepts in an understandable way, and has helped develop software for graphically understanding large complex datasets. For the past 8 years, she has focused on statistical issues in Alzheimer's disease such as identifying appropriate outcomes, addressing measurement issues, demonstrating disease modification and optimizing clinical trial design. She has interacted with the division of Neurology products at the FDA and with the EMEA through scientific advice regarding these issues. She is currently an independent consultant in the pharmaceutical industry, primarily supporting clinical trial design and optimization in neurological indications, particularly Alzheimer's disease. She has researched methods for discerning disease modification of a treatment, and has proposed novel approaches to this problem.
Director, Statistical Programming
Stephanie Stanworth has a Master's degree in Statistics and over 20 years experience as a SAS programmer/Statistician. She has extensive experience in clinical trials reporting, simulation programming and analyzing complex data sets. She has been working with Pentara Corporation for 4 years.


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